https://doi.org/10.1140/epjd/s10053-022-00408-4
Regular Article – Atomic and Molecular Collisions
A prospective study on ionization of endohedral metallofullerene as cryo-electron microscopy biomarker using relativistic electron scattering
1
School of Technology Management and Engineering, SVKM’s NMIMS, 453112, Indore, India
2
Department of Physics, University College of Science, Mohanlal Sukhadia University, 313001, Udaipur, India
Received:
19
February
2022
Accepted:
26
April
2022
Published online:
11
May
2022
Since the discovery of endohedral metallofullerene, it has always been attractive among researchers in various fields of utilities. An encapsulated Au atom with fullerene can be an ideal active agent for enhancing the response of the ligand docking site of protein for cryo-electron microscopy. In this study, we have used high energy electron scattering to ionize encapsulated Au atom, which is docked in protein’s cavity. It is to identify the capabilities of encapsulated Au atom as a biomarker for cryo-electron microscopy. We have applied a fully relativistic calculation to calculate differential cross section and spin asymmetry with relativistic wave functions at the high impact energy. The obtained results reflect that endohedral metallofullerene can enhance the scattering amplitude of protein, which could be a biosensing tool for cryo-EM, as well as the study of drug docking with any protein molecule.
© The Author(s), under exclusive licence to EDP Sciences, SIF and Springer-Verlag GmbH Germany, part of Springer Nature 2022
