Eur. Phys. J. D (2017) 71: 210
https://doi.org/10.1140/epjd/e2017-80120-0

Regular Article

Cell survival probability in a spread-out Bragg peak for novel treatment planning^*

¹ Department of Physics, Oakland University, Rochester, Michigan 48309, USA
² MBN Research Center, 60438 Frankfurt am Main, Germany

^a e-mail: surdutov@oakland.edu

Received: 21 February 2017
Received in final form: 18 May 2017
Published online: 8 August 2017

Abstract

The problem of variable cell survival probability along the spread-out Bragg peak is one of the long standing problems in planning and optimisation of ion-beam therapy. This problem is considered using the multiscale approach to the physics of ion-beam therapy. The physical reasons for this problem are analysed and understood on a quantitative level. A recipe of solution to this problem is suggested using this approach. This recipe can be used in the design of a novel treatment planning and optimisation based on fundamental science.