https://doi.org/10.1140/epjd/e2017-80120-0
Regular Article
Cell survival probability in a spread-out Bragg peak for novel treatment planning*
1 Department of Physics, Oakland University, Rochester, Michigan 48309, USA
2 MBN Research Center, 60438 Frankfurt am Main, Germany
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Received: 21 February 2017
Received in final form: 18 May 2017
Published online: 8 August 2017
Abstract
The problem of variable cell survival probability along the spread-out Bragg peak is one of the long standing problems in planning and optimisation of ion-beam therapy. This problem is considered using the multiscale approach to the physics of ion-beam therapy. The physical reasons for this problem are analysed and understood on a quantitative level. A recipe of solution to this problem is suggested using this approach. This recipe can be used in the design of a novel treatment planning and optimisation based on fundamental science.
Contribution to the Topical Issue “Dynamics of Systems at the Nanoscale”, edited by Andrey Solov’yov and Andrei Korol.
On leave from A.F. Ioffe Physical Technical Institute, 194021 St. Petersburg, Russia.
© EDP Sciences, Società Italiana di Fisica, Springer-Verlag 2017
