Cell survival probability in a spread-out Bragg peak for novel treatment planning*
1 Department of Physics, Oakland University, Rochester, Michigan 48309, USA
2 MBN Research Center, 60438 Frankfurt am Main, Germany
Received: 21 February 2017
Received in final form: 18 May 2017
Published online: 8 August 2017
The problem of variable cell survival probability along the spread-out Bragg peak is one of the long standing problems in planning and optimisation of ion-beam therapy. This problem is considered using the multiscale approach to the physics of ion-beam therapy. The physical reasons for this problem are analysed and understood on a quantitative level. A recipe of solution to this problem is suggested using this approach. This recipe can be used in the design of a novel treatment planning and optimisation based on fundamental science.
© EDP Sciences, Società Italiana di Fisica, Springer-Verlag 2017