https://doi.org/10.1140/epjd/e2015-60036-5
Regular Article
Radio- and photosensitization of DNA with compounds containing platinum and bromine atoms*
1 Gdańsk University of Technology,
Faculty of Ocean Engineering and Ship Technology, Department of Control and Energy
Engineering, G. Narutowicza
11/12, 80-233
Gdańsk,
Poland
2 Department of Physical Sciences, The
Open University, MK7
6AA, Milton Keynes,
UK
3 Radiation Laboratory and Department
of Physics, University of Notre Dame, Notre Dame, 46556, IN, USA
4 ISA, Department of Physics and
Astronomy, Aarhus University, 8000
Aarhus C,
Denmark
a e-mail: smialek@pg.gda.pl
Received:
19
January
2015
Received in final form:
23
March
2015
Published online:
5
May
2015
Irradiations of plasmid DNA by both X-rays and UV light in the presence and absence of compounds containing platinum and bromine atoms were performed in order to asses the sensitization potential of these compounds. Plasmid DNA pBR322 was incubated with platinum (II) bromide, hydrogen hexabromoplatinate (IV), hydrogen hexahydroxyplatinate (IV) and sodium hexahydroxyplatinate (IV). Incubation was followed by X-ray or UV irradiations. It was found that amongst the sensitizers tested, during irradiations carried out in the presence of platinum (II) bromide, the highest levels of double strand breaks formation upon X-ray treatment were recorded. In contrast much less damage was induced by UV light. Data presented here suggests that this compound may be a promising radiosensitizer for cancer treatment.
© The Author(s) 2015. This article is published with open access at Springerlink.com
This is an open access article distributed
under the terms of the Creative Commons Attribution License 4.0, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
