Regular Article

Calculation of survival probabilities for cells exposed to high ion fluences^★

¹ Department of Physics, Oakland University, Rochester, MI 48309, USA
² MBN Research Center, 60438 Frankfurt am Main, Germany
³ On leave from A.F. Ioffe Physical Technical Institute, 194021 St. Petersburg, Russia

^a e-mail: surdutov@oakland.edu

Received: 19 January 2018
Received in final form: 1 June 2018
Published online: 7 August 2018

Abstract

A methodology of calculations of survival curves with an account for ion tracks interference is developed using the multiscale approach to the physics of radiation damage with ions. The method is applied to cells, for which shouldered survival curves are obtained; however, it can be applied to plasmid DNA and other targets. The recipe is designed for both high and low values of linear energy transfer.