Modeling receptor-ligand binding kinetics in immunological synapse formation
Frankfurt Institute for Advanced Studies (FIAS), Ruth-Moufang-Str. 1, 60438 Frankfurt-am-Main, Germany
Corresponding author: a firstname.lastname@example.org
Published online: 7 May 2008
The formation of an immunological synapse between two immune cells is a central process in immunity allowing the exchange of information that is of direct relevance for the cells' activation states. The macromolecules at the cell-cell interface form a characteristic spatial pattern whose functional impact is largely unknown today. We perform computer simulations of the immunological synapse formation using an agent-based model approach that monitors the motion and interaction of individual molecules and takes the binding kinetics of receptors and ligands explicitly into account. The emerging molecular patterns are in agreement with those observed in geometrically repatterned immunological synapses. Furthermore, our model predicts that the diversity of molecular patterns, including dynamic and multifocal structures, is directly related to the receptor-ligand binding affinity.
PACS: 87.18.-Hy – Biological complexity / 82.39.Rt – Reactions in complex biological systems / 82.40.Np – Temporal and spatial patterns in surface reactions / 87.10.Hk – Lattice models
© EDP Sciences, Società Italiana di Fisica, Springer-Verlag, 2008